Emepelle is specially formulated for Estrogen Deficient Skin. Improves noticeable dryness, dullness, sagging, thinning, fine lines and/or wrinkling of facial skin. Estrogen Deficient Skin typically becomes apparent in perimenopause and menopause, when estrogen levels in the body begin to decline. If you feel like your moisturizer is no longer working or like your skin has lost its youthful “glow”, you may be experiencing Estrogen Deficient Skin. LUXURIOUS. NOURISHING. RESTORATIVE. Emepelle is part of Biopelle, a leader in professional, clinically-proven skincare products.